Queryable text covering function, structure, and context.
What changes is not the data.It’s the text.
We synthesize metadata, annotations, and computed features into profiles optimized for search.
- Ligand appears as an internal code (A1CHN), not usable chemistry
- No pocket information (size, hydrophobicity, accessibility)
- No in-depth functional description
Human synaptic vesicle protein 2A (SV2A) is a multi-pass membrane protein that facilitates regulated neurotransmitter release and selectively enhances low‑frequency synaptic transmission. The structure shows Major Facilitator Superfamily / sugar-transporter–like transmembrane domains and an inhibitor, UCB7361, bound in the transmembrane region.
- Ligand identified as inhibitor
- Pocket characteristics described
- Biological role detailed
Ask questions a search form can’t express.
Each query below mixes biological roles, binding-site character, and experimental conditions in a single sentence. Click any card to see real results.
enzymes with buried hydrophobic active site pocket bound to noncovalent drug-like inhibitor
Pocket physics + ligand role — not searchable as structured fields.
CRISPR Cas9 or Cas12 endonuclease ternary complex with guide RNA and target DNA
Functional state: protein + RNA + DNA present together.
integral multi-pass transmembrane protein with enclosed intramembrane hydrophobic cavity bound to small-molecule drug
Membrane-embedded binding pockets — not just any hydrophobic cavity.
vertebrate hemoglobin tetramer oxygen transport protein excluding human
Function + assembly + organism exclusion in one query.
Why semantic search wins here
Structural biology queries are multi-dimensional by nature. Keyword search forces you to flatten them.
Multi-dimensional queries
One query can cross every dimension of the deposited record — from molecular role to pocket shape to crystallization conditions. No need to chain field-based searches or browse ontology trees.
Concept-level search
Search by ideas — "intersubunit pocket," "intramembrane cavity," "post-hydrolysis conformation" — not only IDs, gene names, or controlled vocabulary.
Every entry, equally searchable
An AI chatbot returns a handful of well-known hits skewed by training frequency. Protplex lets you scroll through hundreds of results — including obscure depositions — because semantic search ranks every entry on the same footing.
Expanding thesearch surface
Today you can search by molecular role, binding character, and assembly. We’re adding dimensions that matter most for experimental reuse — so you can find structures worth building on, not just structures that match a keyword.
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