The PDB,searchable by your AI.

240,000+ proteins, one tool call away.

AI chat
Find me kinase scaffolds with non-canonical inhibitors, from non-mammalian organisms.
You
AI alone

Sure! Some well-known kinases with unusual inhibitors:

1ATPPKA + ATP analog
2SRCc-Src + PP1
1IEPAbl + imatinib

The same three your textbook cites.

AI + Protplex
Searched 240k entries, filtered human kinases, ranked by ligand novelty:
3K2L

Calcium-dependent kinase from a malaria parasite. Targets a selectivity pocket absent in other human kinases.

…and 44 more.

Protplex is a tool your AI calls to actually search the PDB, not recalling entries from memory.

The problem

AI agents only knowthe famous proteins.

LLMs keep quoting the same few thousand entries, ignoring most of the PDB.

What an LLM “knows” from the PDB
over-citedthe long tail
~15% over-represented·~85% almost invisible
Citation bias

Famous proteins, which get cited often, are those your AI learns.

No real index

It can recall PDB IDs from memory, but cannot traverse the database by function or structure.

Bland answers

You need sharp answers to specific questions about a niche enzyme or organism, not generic responses.

Our approach

We re-index the PDBfor AI agents.

Function, biology, ligands, structure, organism, experiments, literature.
Every entry distilled into a profile your AI can actually search.

01 / Disparate Data
240,000+ PDBs
UniProt & GO
Computed metrics
02 / Synthesis text
Structured Profile

Queryable text covering function, structure, and context.

FunctionChemistryBinding
Same record, different surface

What changes is not the data.It’s the text.

We synthesize metadata, annotations, and computed features into profiles optimized for search.

BeforeTraditional PDB entry
9PC9
Title
Structure of Synaptic Vesicle Protein 2A Bound to UCB7361
Identifiers / source
Homo sapiens · Electron microscopy, 2.91 Å
Protein family
PF00083
Ligands
A1CHN (Subject of Investigation/LOI)
What’s missing
  • Ligand appears as an internal code (A1CHN), not usable chemistry
  • No pocket information (size, hydrophobicity, accessibility)
  • No in-depth functional description
With ProtplexStructured profile
9PC9

Human synaptic vesicle protein 2A (SV2A) is a multi-pass membrane protein that facilitates regulated neurotransmitter release and selectively enhances low‑frequency synaptic transmission. The structure shows Major Facilitator Superfamily / sugar-transporter–like transmembrane domains and an inhibitor, UCB7361, bound in the transmembrane region.

Filled in
  • Ligand identified as inhibitor
  • Pocket characteristics described
  • Biological role detailed

Why semantic search wins here

Structural-biology queries are multi-dimensional. Keyword search flattens them.

Multi-dimensional queries

Cross function, ligand, pocket, organism, and method in one shot.

Concept-level search

"Intersubunit pocket", "post-hydrolysis state" — not only IDs and gene names.

Every entry, equal footing

Obscure depositions rank alongside textbook ones. No citation bias.

What’s next

Expanding thesearch surface

Today you can search by molecular role, binding character, and assembly. We’re adding dimensions that matter most for experimental reuse — so you can find structures worth building on, not just structures that match a keyword.

Functional states
Search by biological state: apo vs inhibitor-bound, open vs closed, pre- vs post-cleavage.
Pocket geometry
Find proteins by the character of their binding sites: buried cavities, intersubunit pockets, membrane-embedded channels.
Experimental context
Match lab conditions that matter for replication: pH, cofactors, detergents, constructs, method, and resolution.

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